Gilead CEO Daniel O’Day said on the company’s first quarter earnings call this week that “it’s too premature” to tell what the business model for remdesivir might be.
“Our focus will be on making sure we come up with a sustainable model that allows us to provide remdesivir to patients around the globe, that is intent on providing access and affordability,” O’Day said. “We’re just now going through the clinical data, the demand scenarios, the regulatory approvals.”
“They need to have some sort of assurance that they will recoup their investments,” Piper Sandler analyst Tyler Van Buren said.
A promising potential Covid-19 treatment
The study showed patients who took remdesivir recovered faster than patients who did not. The drug improved recovery time for coronavirus patients to 11 days from 15 and demonstrated numerical benefits to mortality — the number of patients who died of Covid-19 — though there were too few participants to prove at this point that remdesivir reduces mortality with statistical significance.
The company says it has not yet made a decision about how much it will charge for the drug after the donated supply is depleted.
“Given the continued uncertainty in the trajectory of the pandemic and in remdesivir clinical data, it’s premature to define what the right post-donation business model is to create a sustainable long term supply for global needs,” CFO Andrew Dickinson said on the call, adding that the company plans to provide an update on its earnings call for the June quarter.
In theory, the drug could be a “blockbuster” for the company, even if it were moderately priced, Raymond James analyst Steven Seedhouse said. If the company’s reaches its hoped-for treatment of 1 million Covid-19 patients by year’s end and more in 2021 even at a price of several hundred dollars per treatment, Gilead could be looking at close to a billion dollars in revenue in a relatively short time period.
But Seedhouse said he’s skeptical the company will charge for its work.
Other analysts have taken a similar stance.
“The company should be commended for its efforts in so quickly addressing this public health emergency,” JPMorgan analyst Cory Kasimov said in a recent note.”But we still feel it’s unlikely to result in tangible, long-term cash flows,” JPMorgan analyst Cory Kasimov said in a recent note.
Profiting amid a pandemic
Some lawmakers and activists have called on Congress to intervene to ensure that remdesivir and other potential Covid-19 treatments and vaccines are priced affordably.
“To beat this pandemic, it’s clear we need better laws that regulate drug corporations to ensure that everyone — no matter where they come from or what they look like — can afford Covid-19Reme treatments,” Minnesota Attorney General Keith Ellison said in a release. “That’s why I’m calling on Congress to take swift action to crack down on pandemic profiteering.”
But running up the cost of remdesivir, if it is proven effective in treating Covid-19, could be deeply harmful to Gilead’s image, according to Seedhouse. Preserving the company’s reputation, he said, may end up being more valuable than recouping the $1 billion it plans to spend this year on development, research and manufacturing work on remdesivir.
“This is a company that spends billions every year anyways on research and development that doesn’t pan out,” Seedhouse said. “Or is it worth more to be the poster child for a responsible biopharma company that’s doing the right thing? … The sentiment and perception of the company matters as much as the EPS they print.”
Gilead CFO Dickinson stressed that the company wants to keep remdesivir “both accessible and affordable to governments and patients around the world.”
Potential pricing models
Experts say it’s important to start the conversation about a fair price for remdesivir now, before Gilead’s donated supplies run out and ahead of any official approval.
The report details several potential models for pricing remdesivir, which the organization said will be updated as more data becomes available.
The first model, a “cost recovery” approach, takes into account the marginal cost of producing additional doses of remdesivir, and the research and development costs put in by the company. The initial analysis sets the company’s research and development costs at zero, because the drug was developed as a hepatitis C treatment prior to coronavirus.
That model sets the price of one, 10-day course of remdesivir for one Covid-19 patient at $10.
The second uses an analysis based on “quality-adjusted life years” gained by the drug, a model often used for drug pricing that considers how much a medication can lengthen and improve the quality of a person’s life.
That model suggests that remdesivir be priced starting at $390 per 10-day course of treatment if the drug is ultimately found to have no mortality reduction benefits, and $4,460 per course of treatment if the drug is found to reduce mortality.
Even that highest price — nearly $4,500 per 10-day treatment — is fairly affordable compared to other, similar types of emergency intervention drugs that reduce mortality, said Van Buren, the Piper Sandler analyst, calling it “one of the most reasonable price tags you can see on a drug with mortality benefits.”
For the most part, that amount also would not be paid by patients, but by insurance companies or government insurance programs.
The ICER study is not meant to lay out exact pricing for remdesivir, a decision that will ultimately be up to Gilead, ICER’s vice president of communications and outreach David Whitrap said.
“What we’re hoping to do is strike a conversation,” Whitrap said. “We think now is the time, before there is a price for this treatment, for the US and the pharmaceutical industry to think about how we want to incentivize and reward this sort of therapy, or any sort of therapy for Covid-19, in a way that accelerates drug development and is also affordable and accessible for patients.”